Maximizing Reliability: Maintenance & Real-World Experience with Agilent Autosamplers

Agilent autosamplers are engineered for performance—but long-term reliability depends on maintenance and real-world usage patterns.

From Agilent’s own support, regular preventative maintenance is emphasized to avoid issues like noisy baselines, reduced column life, lower sensitivity, and variable retention times. They offer dedicated sampler and maintenance kits encompassing consumables, spare parts, and upgrade components, all tested to ensure system performance and lab efficiency.

In practical terms, users on forums such as Reddit have reported mixed experiences. One commenter remarked that older Agilent 1100 series instruments felt more robust—likening them to “the Nokia phones of LC systems”—while newer Infinity models sometimes suffer build quality issues, e.g., fragile compartment doors:

“Everyone knows those 1100s are the Nokia phones of LC systems… 3 of them have broken sample compartment doors”

Despite that, users still prefer newer Infinity autosamplers over competitor models—a testament to their operational advantages and trusted performance, even if certain parts may feel less durable.

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To mitigate downtime and enhance reliability, labs should:

Schedule regular maintenance using Agilent’s recommended kits;

Monitor consumables like needles and seals;

Keep logs of maintenance history—GLP features support this in some models (e.g., G1329B);

Address wear and tear before component failure affects performance.

By combining manufacturer-recommended maintenance with awareness of real-world limitations, labs can ensure that Agilent autosamplers continue delivering on their core strengths: precision, automation, and throughput.